BDBM384948 2-[(3S)-3-fluoropyrrolidin-1-yl]-N- {(1R)-1-[3-fluoro-4- (trifluoromethyl)phenyl]-2- methylpropyl}-6-oxo-1,6- dihydropyrimidine-4-carboxamide::US10285989, Example 168

SMILES CC(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)N1CC[C@H](F)C1)c1ccc(c(F)c1)C(F)(F)F

InChI Key InChIKey=GVGWGPGGHZWNPV-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 384948   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384948(2-[(3S)-3-fluoropyrrolidin-1-yl]-N- {(1R)-1-[3-flu...)
Affinity DataKi:  0.470nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384948(2-[(3S)-3-fluoropyrrolidin-1-yl]-N- {(1R)-1-[3-flu...)
Affinity DataKi:  0.5nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent