BDBM384945 2-[(3S)-3-fluoropyrrolidin-1-yl]-N- [(1R)-1-{3-fluoro-4- [(trifluoromethyl)sulfanyl]phenyl}- 2-methylpropyl]-6-oxo-1,6- dihydropyrimidine-4-carboxamide::US10285989, Example 165

SMILES CC(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)N1CC[C@H](F)C1)c1ccc(SC(F)(F)F)c(F)c1

InChI Key InChIKey=QRRQFKQGQDORKW-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 384945   

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384945(2-[(3S)-3-fluoropyrrolidin-1-yl]-N- [(1R)-1-{3-flu...)
Affinity DataKi:  0.330nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384945(2-[(3S)-3-fluoropyrrolidin-1-yl]-N- [(1R)-1-{3-flu...)
Affinity DataKi:  0.450nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384945(2-[(3S)-3-fluoropyrrolidin-1-yl]-N- [(1R)-1-{3-flu...)
Affinity DataKi:  0.5nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent