BDBM384929 2-azetidin-1-yl-N- [(1R)-2-methyl-1- {4-[(trifluoromethyl) sulfanyl]phenyl}propyl]-6- oxo-1,6- dihydropyrimidine- 4-carboxamide::US10285989, Example 148

SMILES CC(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)N1CCC1)c1ccc(SC(F)(F)F)cc1

InChI Key InChIKey=CJGARQRHMUKIDJ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 384929   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384929(2-azetidin-1-yl-N- [(1R)-2-methyl-1- {4-[(trifluor...)
Affinity DataKi:  0.200nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384929(2-azetidin-1-yl-N- [(1R)-2-methyl-1- {4-[(trifluor...)
Affinity DataKi:  0.420nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent