BDBM384927 6-oxo-2-pyrrolidin- 1-yl-N-[(1R)-1-{4- [(trifluoromethyl) sulfanyl]phenyl} ethyl]-1,6-dihydro- pyrimidine-4- carboxamide::US10285989, Example 146

SMILES C[C@@H](NC(=O)c1cc(=O)[nH]c(n1)N1CCCC1)c1ccc(SC(F)(F)F)cc1

InChI Key InChIKey=OQLSTFIYIJCUQA-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 384927   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384927(6-oxo-2-pyrrolidin- 1-yl-N-[(1R)-1-{4- [(trifluoro...)
Affinity DataKi:  0.360nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384927(6-oxo-2-pyrrolidin- 1-yl-N-[(1R)-1-{4- [(trifluoro...)
Affinity DataKi:  0.430nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent