BDBM384905 (S)- or (R)-2-(dimethylamino)-N-{1-[3- fluoro-4-(1- methylcyclopropyl)phenyl]- 2,2-dimethylpropyl}-6-oxo-1,6- dihydropyrimidine-4-carboxamide::US10285989, Example 123::US10285989, Example 124

SMILES CN(C)c1nc(cc(=O)[nH]1)C(=O)NC(c1ccc(c(F)c1)C1(C)CC1)C(C)(C)C

InChI Key InChIKey=PIFTXPZRLQFNAU-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 384905   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384905((S)- or (R)-2-(dimethylamino)-N-{1-[3- fluoro-4-(1...)
Affinity DataKi:  0.340nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384905((S)- or (R)-2-(dimethylamino)-N-{1-[3- fluoro-4-(1...)
Affinity DataKi:  0.450nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384905((S)- or (R)-2-(dimethylamino)-N-{1-[3- fluoro-4-(1...)
Affinity DataKi:  167nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent