BDBM384897 N-[(R)-cyclopropyl(4- cyclopropylphenyl)methyl]-6-oxo-2- pyrrolidine-1-yl-1,6-dihydropyrimidine- 4-carboxamide::US10285989, Example 113

SMILES O=C(N[C@H](C1CC1)c1ccc(cc1)C1CC1)c1cc(=O)[nH]c(n1)N1CCCC1

InChI Key InChIKey=QCWLMXPBJJLRFV-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 384897   

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384897(N-[(R)-cyclopropyl(4- cyclopropylphenyl)methyl]-6-...)
Affinity DataKi:  0.360nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384897(N-[(R)-cyclopropyl(4- cyclopropylphenyl)methyl]-6-...)
Affinity DataKi:  0.630nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384897(N-[(R)-cyclopropyl(4- cyclopropylphenyl)methyl]-6-...)
Affinity DataKi:  0.650nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent