BDBM384895 N-[(R)-cyclopropyl{4- [(trifluoromethyl)sulfanyl]phenyl} methyl]-2-(dimethylamino)-6-oxo-1,6- dihydropyrimidine-4-carboxamide::US10285989, Example 111

SMILES CN(C)c1nc(cc(=O)[nH]1)C(=O)N[C@H](C1CC1)c1ccc(SC(F)(F)F)cc1

InChI Key InChIKey=RNDFNWPEBWZJIC-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 384895   

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384895(N-[(R)-cyclopropyl{4- [(trifluoromethyl)sulfanyl]p...)
Affinity DataKi:  0.410nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384895(N-[(R)-cyclopropyl{4- [(trifluoromethyl)sulfanyl]p...)
Affinity DataKi:  0.800nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384895(N-[(R)-cyclopropyl{4- [(trifluoromethyl)sulfanyl]p...)
Affinity DataKi:  0.900nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent