BDBM384844 N-{(1R)-1-[4- (difluoromethyl)phenyl]-2,2- dimethylpropyl}-2-(dimethylamino)- 6-oxo-1,6-dihydropyrimidine-4- carboxamide::US10285989, Example 60

SMILES CN(C)c1nc(cc(=O)[nH]1)C(=O)N[C@@H](c1ccc(cc1)C(F)F)C(C)(C)C

InChI Key InChIKey=AQYRVUXVMRWPNA-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 384844   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384844(N-{(1R)-1-[4- (difluoromethyl)phenyl]-2,2- dimethy...)
Affinity DataKi:  0.290nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384844(N-{(1R)-1-[4- (difluoromethyl)phenyl]-2,2- dimethy...)
Affinity DataKi:  0.420nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent