BDBM384841 2-(dimethylamino)-N-{(R)-(1- methylcyclopropyl)[4-(pentafluoro-lambda6- sulfanyl)phenyl]methyl}-6-oxo-1,6- dihydropyrimidine-4-carboxamide::US10285989, Example 57

SMILES CN(C)c1nc(cc(=O)[nH]1)C(=O)N[C@@H](c1ccc(cc1)S(F)(F)(F)(F)F)C1(C)CC1

InChI Key InChIKey=JKSGRFFRUWZGBA-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 384841   

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384841(2-(dimethylamino)-N-{(R)-(1- methylcyclopropyl)[4-...)
Affinity DataKi:  0.280nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384841(2-(dimethylamino)-N-{(R)-(1- methylcyclopropyl)[4-...)
Affinity DataKi:  0.310nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent