BDBM384664 4-((5)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-6-chloro-2-(14 (R)-2-hydroxypropyl)azetidin-3-yl)-3-methoxybenzonitrile ::US9932341, Example 362

SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C[C@H](C)O)C1)[C@H](C)n1nc(C)c2c(N)ncnc12

InChI Key InChIKey=KLKCQNBHXXLCHY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 384664   

LigandPNGBDBM384664(4-((5)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrim...)
Affinity DataIC50: 10nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
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LigandPNGBDBM384664(4-((5)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrim...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed