BDBM384357 US9932327, Compound Flavopiridol

SMILES C[N@]1CC[C@@H]([C@@H](C1)O)c2c(cc(c3c2OC(=CC3=O)c4ccccc4Cl)O)O

InChI Key InChIKey=BIIVYFLTOXDAOV-UHFFFAOYSA-N

Data  2 IC50

PDB links: 5 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 384357   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
The Council of Scientific & Industrial Research

US Patent
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataIC50: 170nMAssay Description:CDK-2/cyclin A (5-20 mU diluted in 50 mM Hepes pH 7.5, 1 mM DTT, 0.02% Brij35, 100 mM NaCl) was assayed against Histone H1 in a final volume of 25.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
The Council of Scientific & Industrial Research

US Patent
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataIC50: 20nMAssay Description:CDK-9/Cyclin T1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 1 mg/ml BSA, 0.1% mercaptoethanol) was assayed against a substrate peptide (YSPTS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)