BDBM384357 US9932327, Compound Flavopiridol

SMILES C[N@]1CC[C@@H]([C@@H](C1)O)c2c(cc(c3c2OC(=CC3=O)c4ccccc4Cl)O)O

InChI Key InChIKey=BIIVYFLTOXDAOV-UHFFFAOYSA-N

Data  1 KI  16 IC50  2 Kd  1 EC50

PDB links: 5 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 384357   

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataIC50: 11nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataKd:  96nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataIC50: 103nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataIC50: 305nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataIC50: 38nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataIC50: 177nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataEC50:  55nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
The Council of Scientific & Industrial Research

US Patent
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataIC50: 170nMAssay Description:CDK-2/cyclin A (5-20 mU diluted in 50 mM Hepes pH 7.5, 1 mM DTT, 0.02% Brij35, 100 mM NaCl) was assayed against Histone H1 in a final volume of 25.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataIC50: 40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein kinase C epsilon type(Human)
Sunesis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataIC50: 480nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein kinase C delta type(Human)
Sunesis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataIC50: 890nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataIC50: 300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataIC50: 170nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
The Council of Scientific & Industrial Research

US Patent
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataIC50: 20nMAssay Description:CDK-9/Cyclin T1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 1 mg/ml BSA, 0.1% mercaptoethanol) was assayed against a substrate peptide (YSPTS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataKi:  41nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed