BDBM384179 8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-2,2-difluoro-8-azaspiro[4.5]decan-1-amine::US10280171, Example 65A::US10280171, Example 65B
SMILES NC1C(F)(F)CC[C@]11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl
InChI Key InChIKey=LNKXXCNDICLLOS-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 384179
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System
US Patent
The University of Texas System
US Patent
Affinity DataIC50: 235nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System
US Patent
The University of Texas System
US Patent
Affinity DataIC50: 93nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System
US Patent
The University of Texas System
US Patent
Affinity DataIC50: 471nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System
US Patent
The University of Texas System
US Patent
Affinity DataIC50: 165nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair