BDBM384174 (4-amino-1-(3-(2- chlorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)- piperidin-4-yl)- methanol::US10280171, Example 61::US10851110, Example 61::US11529347, Compound 56
SMILES NC1(CO)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccccc1Cl
InChI Key InChIKey=DCZHDAUEYSJCLK-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 384174
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System
US Patent
The University of Texas System
US Patent
Affinity DataIC50: 401nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System
US Patent
The University of Texas System
US Patent
Affinity DataIC50: 221nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System
US Patent
The University of Texas System
US Patent
Affinity DataIC50: 401nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair