BDBM384143 (1-(3-(2-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin- methanamine::US10280171, Example 29::US10851110, Example 29::US11466017, Example 29::US11529347, Compound 43

SMILES CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccccc1Cl

InChI Key InChIKey=JCYHCBVXAFUBRD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 384143   

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384143(US10280171, Example 29 | (1-(3-(2-chloro- phenyl)-...)
Affinity DataIC50: 178nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
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TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384143(US10280171, Example 29 | (1-(3-(2-chloro- phenyl)-...)
Affinity DataIC50: 87nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384143(US10280171, Example 29 | (1-(3-(2-chloro- phenyl)-...)
Affinity DataIC50: 178nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384143(US10280171, Example 29 | (1-(3-(2-chloro- phenyl)-...)
Affinity DataIC50: 178nMAssay Description:Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
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TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

US Patent
LigandPNGBDBM384143(US10280171, Example 29 | (1-(3-(2-chloro- phenyl)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent