BDBM382125 6-(4-(2,4-difluorobenzyl)piperazin-1-yl)-3-((2-(dimethylamino)ethoxy)methyl)-5-(isopropylamino)pyrazine-2-carbonitrile::US10000468, Example 34::US10273225, Example 34

SMILES CC(C)Nc1nc(COCCN(C)C)c(nc1N1CCN(Cc2ccc(F)cc2F)CC1)C#N

InChI Key InChIKey=PVVAAMDQVTZQGE-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 382125   

TargetG-protein coupled receptor 6(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM382125(US10000468, Example 34 | 6-(4-(2,4-difluorobenzyl)...)
Affinity DataEC50:  6.25E+4nMAssay Description:This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
Go to US Patent

TargetG-protein coupled receptor 6(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM382125(US10000468, Example 34 | 6-(4-(2,4-difluorobenzyl)...)
Affinity DataEC50:  6.25E+4nMAssay Description:This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
Go to US Patent