BDBM381687 US10272079, Compound 44

SMILES CNC(=O)CN(CCN(CC(O)=O)CC(=O)NCCOCCOCCNC(=O)NCCOCCOCCOCCOc1cccc(c1)-c1nc(NC(N)=N)nc2ccc(Cl)cc12)CC(O)=O

InChI Key InChIKey=KCOSOYIKLYSNFY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 381687   

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381687(US10272079, Compound 44)
Affinity DataIC50: 20nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
Go to US Patent

TargetSodium/hydrogen exchanger 3(Human)
Ardelyx

US Patent
LigandPNGBDBM381687(US10272079, Compound 44)
Affinity DataIC50: 12.6nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
Go to US Patent