BDBM381367 4-chloro-1-(1,1-dioxidotetrahydro- 2H-thiopyran-4-yl)-N-(4- isopropylphenyl)-3-methyl-1H- pyrazolo[3,4-b]pyridine-5- carboxamide::US10272074, Example 200

SMILES CC(C)c1ccc(NC(=O)c2cnc3n(nc(C)c3c2Cl)C2CCS(=O)(=O)CC2)cc1

InChI Key InChIKey=CHKJYEQSCOKLGG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 381367   

TargetGlucocorticoid receptor(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM381367(4-chloro-1-(1,1-dioxidotetrahydro- 2H-thiopyran-4-...)
Affinity DataIC50: 50nMAssay Description:The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
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