BDBM380765 (R)-6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-methyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-2-(2-methoxypyridin-3-yl)-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one::US9890166, Example 153

SMILES COc1ncccc1-c1nc2C(=O)N([C@@H](c2[nH]1)c1ccc(Cl)cc1)c1cc(C)c2nnc(C(F)F)n2c1

InChI Key InChIKey=VFDAORCFAAAXRV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 380765   

TargetBromodomain-containing protein 4(Human)
Novartis

US Patent
LigandPNGBDBM380765((R)-6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-met...)
Affinity DataIC50: 13nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandPNGBDBM380765((R)-6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-met...)
Affinity DataIC50: 23nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetBromodomain-containing protein 2(Human)
Novartis

US Patent
LigandPNGBDBM380765((R)-6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-met...)
Affinity DataIC50: 25nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandPNGBDBM380765((R)-6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-met...)
Affinity DataIC50: 2.89E+4nMAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent