BDBM38029 US10093646, Example 9::US10774065, Example 9::US11401259, Example 9

SMILES NCC1CCN(CC1)c1cnc(c(N)n1)-c1cccc(Cl)c1Cl

InChI Key InChIKey=RIVHGLWVVDJGBM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 38029   

LigandPNGBDBM38029(US10093646, Example 9 | US10774065, Example 9 | US...)
Affinity DataIC50: 358nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
Go to US Patent

LigandPNGBDBM38029(US10093646, Example 9 | US10774065, Example 9 | US...)
Affinity DataIC50: 358nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
Go to US Patent

LigandPNGBDBM38029(US10093646, Example 9 | US10774065, Example 9 | US...)
Affinity DataIC50: 358nMAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
Go to US Patent

LigandPNGBDBM38029(US10093646, Example 9 | US10774065, Example 9 | US...)
Affinity DataIC50: 425nMAssay Description:Allosteric inhibition of wild-type human SHP2 (1 to 535 residues) using DiFMUP and 2p-IRS1 peptide as substrates preincubated for 1 hr and followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
LigandPNGBDBM38029(US10093646, Example 9 | US10774065, Example 9 | US...)
Affinity DataIC50: 1.00E+4nMAssay Description:Allosteric inhibition of recombinant human SHP2 PTP domain (237 to 535 residues) using DiFMUP as substrate preincubated for 30 mins and followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed