BDBM379778 US9926281, Compound 235

SMILES CC(CC1(CCNC(=O)OC(C)(C)C)NC(=O)NC1=O)C(=O)N1CCN(CC1)c1ccc(F)c(F)c1

InChI Key InChIKey=XUOKZLGAMXUMSE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 379778   

LigandPNGBDBM379778(US9926281, Compound 235)
Affinity DataIC50: 16nMAssay Description:ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
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LigandPNGBDBM379778(US9926281, Compound 235)
Affinity DataIC50: 1.32E+3nMAssay Description:TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
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Target72 kDa type IV collagenase(Human)
Galapagos

US Patent
LigandPNGBDBM379778(US9926281, Compound 235)
Affinity DataIC50: 2.00E+4nMAssay Description:MMP2: Protocol 2: The basis for the assay is the cleavage of the substrate 390 MMP FRET substrate I (Anaspec, Catalog n#: AS-27076) by human MMP2 (R&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
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TargetCollagenase 3(Human)
Galapagos

US Patent
LigandPNGBDBM379778(US9926281, Compound 235)
Affinity DataIC50: 21.2nMAssay Description:MMP-13:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP13 (Chemicon, Cat #CC06...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
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TargetMatrix metalloproteinase-14(Human)
Galapagos

US Patent
LigandPNGBDBM379778(US9926281, Compound 235)
Affinity DataIC50: 26nMAssay Description:MMP-14:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP14 (Biomol, Cat #SE-259...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
Go to US Patent