BDBM379553 US9926281, Compound 27

SMILES Cc1ccccc1N1CCN(CC1)C(=O)CC[C@]1(NC(=O)NC1=O)c1ccccc1

InChI Key InChIKey=TYWOUTWIECTKOD-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 379553   

TargetADAMTS5(Rat)
Galapagos

US Patent
LigandPNGBDBM379553(US9926281, Compound 27)
Affinity DataIC50: 124nMAssay Description:ADAMTS-4:The basis for the assay is the cleavage of the substrate TBIS-1 (5-FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMTS4For the do...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
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LigandPNGBDBM379553(US9926281, Compound 27)
Affinity DataIC50: 90nMAssay Description:ADAMTS-5:Protocol 1: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
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LigandPNGBDBM379553(US9926281, Compound 27)
Affinity DataIC50: 2.00E+3nMAssay Description:TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
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TargetInterstitial collagenase(Human)
Galapagos

US Patent
LigandPNGBDBM379553(US9926281, Compound 27)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of the proteases human MMP1 was determined at REACTION BIOLOGY (Reaction Biology Corp. 1 Great Valley Parkway, Suite 2 Malvern, Pa. 19355,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
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Target72 kDa type IV collagenase(Human)
Galapagos

US Patent
LigandPNGBDBM379553(US9926281, Compound 27)
Affinity DataIC50: 1.00E+4nMAssay Description:MMP2: Protocol 1: The basis for the assay is the cleavage of the substrate 520 MMP fret substrate XV (Anaspec, Catalog #: AS-60582-01) by human MMP2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
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TargetCollagenase 3(Human)
Galapagos

US Patent
LigandPNGBDBM379553(US9926281, Compound 27)
Affinity DataIC50: 2.00E+4nMAssay Description:MMP-13:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP13 (Chemicon, Cat #CC06...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
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TargetMatrix metalloproteinase-14(Human)
Galapagos

US Patent
LigandPNGBDBM379553(US9926281, Compound 27)
Affinity DataIC50: 2.00E+4nMAssay Description:MMP-14:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP14 (Biomol, Cat #SE-259...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
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LigandPNGBDBM379553(US9926281, Compound 27)
Affinity DataIC50: 84nMAssay Description:Inhibition of human recombinant ADAMTS-5 assessed as cleavage of fluorescent substrate using FAM-TBIS-1 by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed