BDBM379534 US9926281, Compound 6

SMILES Clc1cccc(c1)N1CCN(CC1)C(=O)CCC1(NC(=O)NC1=O)c1ccccc1

InChI Key InChIKey=BLPSVYQVAGCHMF-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 379534   

TargetADAMTS5(Rat)
Galapagos

US Patent
LigandPNGBDBM379534(US9926281, Compound 6)
Affinity DataIC50: 107nMAssay Description:ADAMTS-4:The basis for the assay is the cleavage of the substrate TBIS-1 (5-FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMTS4For the do...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
Go to US Patent

LigandPNGBDBM379534(US9926281, Compound 6)
Affinity DataIC50: 79nMAssay Description:ADAMTS-5:Protocol 1: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
Go to US Patent

LigandPNGBDBM379534(US9926281, Compound 6)
Affinity DataIC50: 86nMAssay Description:ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
Go to US Patent

LigandPNGBDBM379534(US9926281, Compound 6)
Affinity DataIC50: 2.36E+3nMAssay Description:TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
Go to US Patent

Target72 kDa type IV collagenase(Human)
Galapagos

US Patent
LigandPNGBDBM379534(US9926281, Compound 6)
Affinity DataIC50: 379nMAssay Description:MMP2: Protocol 1: The basis for the assay is the cleavage of the substrate 520 MMP fret substrate XV (Anaspec, Catalog #: AS-60582-01) by human MMP2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
Go to US Patent

TargetCollagenase 3(Human)
Galapagos

US Patent
LigandPNGBDBM379534(US9926281, Compound 6)
Affinity DataIC50: 2.15E+3nMAssay Description:MMP-13(2): The basis for the assay is the cleavage of the substrate 520 MMP-fret substrate XV (Anaspec, Catalog #: AS-60582-01) by human MMP13 (Chemi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
Go to US Patent

LigandPNGBDBM379534(US9926281, Compound 6)
Affinity DataIC50: 71nMAssay Description:Inhibition of human recombinant ADAMTS-5 assessed as cleavage of fluorescent substrate using FAM-TBIS-1 by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed