BDBM37947 US10093631, Compound Formula (Ig)

SMILES Oc1[nH]c(=O)[nH]c(=O)c1C(=O)Nc1cc(F)c(O)c(F)c1

InChI Key InChIKey=DFUCKWJYLHPGKA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 37947   

TargetSolute carrier family 22 member 12(Human)
Acquist

US Patent
LigandPNGBDBM37947(US10093631, Compound Formula (Ig))
Affinity DataIC50: 3.55E+3nMAssay Description:URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
Go to US Patent

TargetXanthine dehydrogenase/oxidase(Human)
Acquist

US Patent
LigandPNGBDBM37947(US10093631, Compound Formula (Ig))
Affinity DataIC50: 1.92E+3nMAssay Description:Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
Go to US Patent

TargetSolute carrier family 22 member 12(Human)
Acquist

US Patent
LigandPNGBDBM37947(US10093631, Compound Formula (Ig))
Affinity DataIC50: 3.55E+3nMAssay Description:Displacement of 3H-orotate from URAT1 (unknown origin) stably transfected in CHO cells assessed as reduction in uric acid level by liquid scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Acquist

US Patent
LigandPNGBDBM37947(US10093631, Compound Formula (Ig))
Affinity DataIC50: 1.92E+3nMAssay Description:Inhibition of XO (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed