BDBM379366 2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N,N-dimethylbenzamide::US10266549, Example 245::US10774092, Example 245

SMILES COc1cc(Nc2ncc(Br)c(Oc3ccccc3C(=O)N(C)C)n2)cc(OC)c1OC

InChI Key InChIKey=OBHLHMRQOULBAS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 379366   

TargetSerine/threonine-protein kinase ULK1(Human)
Salk Institute

US Patent
LigandPNGBDBM379366(2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrim...)
Affinity DataIC50: 200nMAssay Description:Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase ULK1(Human)
Salk Institute

US Patent
LigandPNGBDBM379366(2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrim...)
Affinity DataIC50: 200nMAssay Description:ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent