BDBM379139 2-(2-(2-Methoxy-4-morpholinophenylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)-N-methylbenzamide::US10266549, Example 39::US10774092, Example 39

SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)ncc1C(F)(F)F

InChI Key InChIKey=HTMHGVFYKXFPAO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 379139   

TargetSerine/threonine-protein kinase ULK1(Human)
Salk Institute

US Patent
LigandPNGBDBM379139(2-(2-(2-Methoxy-4-morpholinophenylamino)-5-(triflu...)
Affinity DataIC50: 200nMAssay Description:Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetSerine/threonine-protein kinase ULK1(Human)
Salk Institute

US Patent
LigandPNGBDBM379139(2-(2-(2-Methoxy-4-morpholinophenylamino)-5-(triflu...)
Affinity DataIC50: 200nMAssay Description:ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
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TargetFocal adhesion kinase 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM379139(2-(2-(2-Methoxy-4-morpholinophenylamino)-5-(triflu...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of GST-fused FAK (411 to 686 residues)(unknown origin) expressed in baculovirus expression system using poly(Glu:Tyr) as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed