BDBM378912 5,8-dichloro-7-[methoxy(oxetan-3-yl)methyl]-2-[(7-methyl-5-oxo-1,6-dihydropyrrolo[2,3-c]pyridin-4-yl)methyl]-3,4-dihydroisoquinolin-1-one::US10266542, Example 17

SMILES COC(C1COC1)c1cc(Cl)c2CCN(Cc3c4ccn(C)c4c(C)[nH]c3=O)C(=O)c2c1Cl

InChI Key InChIKey=ISTWLICONNUDBJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378912   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378912(US10266542, Example 17 | 5,8-dichloro-7-[methoxy(o...)
Affinity DataIC50: 1nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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