BDBM378908 7-((5,8-dichloro-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-4-methylfuro[3,2-c]pyridin-6(5H)-one::US10266542, Example 14

SMILES Cc1nnn(C)c1-c1cc(Cl)c2CCN(Cc3c4cc[nH]c4c(C)[nH]c3=O)C(=O)c2c1Cl

InChI Key InChIKey=XZUBQBJEILVKEL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378908   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378908(US10266542, Example 14 | 7-((5,8-dichloro-7-(1,4-d...)
Affinity DataIC50: 10nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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