BDBM378901 7-((5,8-dichloro-7-isopropoxy-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-2,4-dimethylfuro[3,2-c]pyridin-6(5H)-one::US10266542, Example 8

SMILES CC(C)Oc1cc(Cl)c2CCN(Cc3c4oc(C)cc4c(C)[nH]c3=O)C(=O)c2c1Cl

InChI Key InChIKey=DRAGISWWEPSDDD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378901   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378901(US10266542, Example 8 | 7-((5,8-dichloro-7-isoprop...)
Affinity DataIC50: 95nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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