BDBM3789 1-Phenylbenzimidazole Analog 6::2-phenyl-1H-1,3-benzodiazole::US9138393, 2-Phenyl benzimidazole::US9144538, 2-Phenyl benzimidazole::cid_12855

SMILES c1ccc(cc1)-c1nc2ccccc2[nH]1

InChI Key InChIKey=DWYHDSLIWMUSOO-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 3789   

TargetPlatelet-derived growth factor receptor beta(Human)
University of Auckland

LigandPNGBDBM3789(2-phenyl-1H-1,3-benzodiazole | cid_12855 | 1-Pheny...)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
University of Auckland

LigandPNGBDBM3789(2-phenyl-1H-1,3-benzodiazole | cid_12855 | 1-Pheny...)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2005
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Mouse)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM3789(2-phenyl-1H-1,3-benzodiazole | cid_12855 | 1-Pheny...)
Affinity DataEC50: >1.95E+5nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2011
Entry Details
PCBioAssay
TargetCytochrome P450 3A4(Human)
The Procter & Gamble

US Patent
LigandPNGBDBM3789(2-phenyl-1H-1,3-benzodiazole | cid_12855 | 1-Pheny...)
Affinity DataIC50: 1.00E+4nMAssay Description:A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2016
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
The Procter & Gamble

US Patent
LigandPNGBDBM3789(2-phenyl-1H-1,3-benzodiazole | cid_12855 | 1-Pheny...)
Affinity DataIC50: 1.00E+4nMAssay Description:Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent

TargetCytochrome P450 2B1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM3789(2-phenyl-1H-1,3-benzodiazole | cid_12855 | 1-Pheny...)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibitory potency to aminopyrine N-demethylase activity (P450) in hepatic microsomes from phenobarbitone-induced rats.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed