BDBM378899 7-[[5-bromo-8-chloro-7-(3,5-dimethyltriazol-4-yl)-1-oxo-3,4-dihydroisoquinolin-2-yl]methyl]-4-methyl-5H-furo[3,2-c]pyridin-6-one::US10266542, Example 7

SMILES Cc1nnn(C)c1-c1cc(Br)c2CCN(Cc3c4occc4c(C)[nH]c3=O)C(=O)c2c1Cl

InChI Key InChIKey=CHUUYLZKSWGRCO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378899   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378899(US10266542, Example 7 | 7-[[5-bromo-8-chloro-7-(3,...)
Affinity DataIC50: 3nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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