BDBM378895 7-((8-chloro-7-isopropoxy-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-4-methylfuro[3,2-c]pyridin-6(5H)-one::US10266542, Example 6

SMILES CC(C)Oc1ccc2CCN(Cc3c4occc4c(C)[nH]c3=O)C(=O)c2c1Cl

InChI Key InChIKey=LICGCCZNKQZQKH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378895   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378895(US10266542, Example 6 | 7-((8-chloro-7-isopropoxy-...)
Affinity DataIC50: 7nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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