BDBM378892 5,8-dichloro-7-isopropoxy-2-((7-methyl-5-oxo-5,6-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one::US10266542, Example 4

SMILES CC(C)Oc1cc(Cl)c2CCN(Cc3c4cc[nH]c4c(C)[nH]c3=O)C(=O)c2c1Cl

InChI Key InChIKey=UVLHABWTYHEZGV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378892   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378892(US10266542, Example 4 | 5,8-dichloro-7-isopropoxy-...)
Affinity DataIC50: 202nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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