BDBM378887 US10266537, Compound 31

SMILES CN1CCC(CC1)n1nc(C#Cc2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)c2c(N)ncnc12

InChI Key InChIKey=LQSGDXCDNZWTJN-UHFFFAOYSA-N

Data  24 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 378887   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 251nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 19nMAssay Description:Inhibition of human CRAF incubated for 40 mins by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 22nMAssay Description:Inhibition of human BRAF incubated for 40 mins by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 12nMAssay Description:Inhibition of human VEGFR2 incubated for 40 mins by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 2nMAssay Description:Inhibition of human SRC incubated for 40 mins by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 600nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by automated Qpatch electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 396nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetCytoplasmic tyrosine-protein kinase BMX(Human)
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 18nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 127nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 7(Human)
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 203nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetDiscoidin domain-containing receptor 2(Human)
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 74nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetEpithelial discoidin domain-containing receptor 1(Human)
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 4nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetProto-oncogene tyrosine-protein kinase Src [1-530](Human)
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 2nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetEphrin type-B receptor 4(Human)
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 11nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetEphrin type-B receptor 2(Human)
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 10nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetEphrin type-A receptor 2(Human)
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 18nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 12nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Blk(Human)
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 12nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Fyn(Human)
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 3nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetTyrosine-protein kinase Yes(Human)
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 1nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 19nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 22nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 5nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetProto-oncogene tyrosine-protein kinase Src [T341M](Human)
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 3.73E+3nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent