BDBM3787 1-Phenylbenzimidazole deriv. 4::1-benzyl-1H-1,3-benzodiazole

SMILES c1ccc(cc1)Cn2cnc3c2cccc3

InChI Key InChIKey=MNEIJGDSFRHGMS-UHFFFAOYSA-N

Data  5 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 3787   

TargetPlatelet-derived growth factor receptor beta(Human)
University of Auckland

LigandPNGBDBM3787(1-benzyl-1H-1,3-benzodiazole | 1-Phenylbenzimidazo...)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
University of Auckland

LigandPNGBDBM3787(1-benzyl-1H-1,3-benzodiazole | 1-Phenylbenzimidazo...)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2005
Entry Details Article
PubMed
LigandPNGBDBM3787(1-benzyl-1H-1,3-benzodiazole | 1-Phenylbenzimidazo...)
Affinity DataIC50: 246nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZ cells using 11-deoxycorticosterone substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM3787(1-benzyl-1H-1,3-benzodiazole | 1-Phenylbenzimidazo...)
Affinity DataIC50: 865nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZ cells using 11-deoxycorticosterone substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM3787(1-benzyl-1H-1,3-benzodiazole | 1-Phenylbenzimidazo...)
Affinity DataKd:  3.00E+5nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM3787(1-benzyl-1H-1,3-benzodiazole | 1-Phenylbenzimidazo...)
Affinity DataIC50: 2.04E+5nMAssay Description:Inhibition of probe-5 binding to human TNFalpha (77 to 233 residues) at 1 nM by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)