BDBM378487 2-oxo-N-(1-((piperidin-4-ylmethyl)sulfonyl)piperidin-4-yl)indoline-5-carboxamide::US10266526, Compound 620

SMILES O=C(NC1CCN(CC1)S(=O)(=O)CC1CCNCC1)c1ccc2NC(=O)Cc2c1

InChI Key InChIKey=FOOUZILBDOSFBJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 378487   

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandPNGBDBM378487(US10266526, Compound 620 | 2-oxo-N-(1-((piperidin-...)
Affinity DataIC50: 68.2nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandPNGBDBM378487(US10266526, Compound 620 | 2-oxo-N-(1-((piperidin-...)
Affinity DataIC50: 70nMAssay Description:Inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using N-terminal GST-tagged ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandPNGBDBM378487(US10266526, Compound 620 | 2-oxo-N-(1-((piperidin-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SMYD3 expressed in HEK293T/17 cells using FLAG-tagged MEKK2 as substrate incubated for 30 mins in low air flow area followed by i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed