BDBM378475 N-((3R,4R)-1-((4-aminopiperidin-1-yl)sulfonyl)-3-methylpiperidin-4-yl)-6-chloro-2-oxoindoline-5-carboxamide::US10266526, Compound 608

SMILES C[C@@H]1CN(CC[C@H]1NC(=O)c1cc2CC(=O)Nc2cc1Cl)S(=O)(=O)N1CCC(N)CC1

InChI Key InChIKey=MURXJAXOCIKLTB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378475   

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandPNGBDBM378475(US10266526, Compound 608 | N-((3R,4R)-1-((4-aminop...)
Affinity DataIC50: 21.4nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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