BDBM377775 (R)-5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-(3-methylbenzyl)phenyl)-1H-pyrazole-4-carboxamide::US10266513, Example 69::US10815213, Example 69

SMILES Cc1cccc(Cc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C#N)c(N)c2C(N)=O)c1

InChI Key InChIKey=ANHVQBCLISLLGS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 377775   

TargetTyrosine-protein kinase BTK(Human)
Pfizer

US Patent
LigandPNGBDBM377775(US10266513, Example 69 | (R)-5-amino-1-(1-cyanopip...)
Affinity DataIC50: 0.600nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Pfizer

US Patent
LigandPNGBDBM377775(US10266513, Example 69 | (R)-5-amino-1-(1-cyanopip...)
Affinity DataIC50: 0.600nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
Go to US Patent