BDBM377689 US10266496, Example 1

SMILES OC(=O)c1ccc(cc1O)-c1cc(cc2ccoc12)C#N

InChI Key InChIKey=JGLRTHVIDGSNOQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 377689   

TargetXanthine dehydrogenase/oxidase(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM377689(US10266496, Example 1)
Affinity DataIC50: 19.6nMAssay Description:The compound was diluted 2.5 fold with a buffer of 50 mM KH2PO4 to give a series of concentrations from 2000 nM to 0.524 nM. Then the diluted solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetSolute carrier family 22 member 12(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM377689(US10266496, Example 1)
Affinity DataIC50: 140nMAssay Description:a. Construction of a Cell Line Stably Expressing hURAT1hURAT1 plasmid was transfected into HEK293T cell, and a cell line stably expressing hURAT1 was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetXanthine dehydrogenase/oxidase(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM377689(US10266496, Example 1)
Affinity DataIC50: 20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM377689(US10266496, Example 1)
Affinity DataIC50: 140nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed