BDBM377188 US10265307, Example 37-2::US10517858, Example 37 (Diastereoisomer 2)::US10828290, Example 37 (Diastereoisomer 2)::US11229631, Example 37 Diastereoisomer 2

SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1c2CC[C@@H](O)c2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F

InChI Key InChIKey=PTORCEYGCGXHDH-UHFFFAOYSA-N

Data  15 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 377188   

TargetSerine/threonine-protein kinase pim-1(Human)
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LigandBDBM377188(US10265307, Example 37-2 | US10517858, Example 37 ...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair

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Date in BDB:
2/7/2020
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TargetSerine/threonine-protein kinase pim-2(Human)
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US Patent

LigandBDBM377188(US10265307, Example 37-2 | US10517858, Example 37 ...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
2/7/2020
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TargetSerine/threonine-protein kinase pim-3(Human)
Incyte

US Patent

LigandBDBM377188(US10265307, Example 37-2 | US10517858, Example 37 ...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetSerine/threonine-protein kinase pim-1(Human)
Incyte

US Patent

LigandBDBM377188(US10265307, Example 37-2 | US10517858, Example 37 ...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.84 compound/DMSO in the assay buffer (...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
10/19/2020
Entry Details
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TargetSerine/threonine-protein kinase pim-2(Human)
Incyte

US Patent

LigandBDBM377188(US10265307, Example 37-2 | US10517858, Example 37 ...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
10/19/2020
Entry Details
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TargetSerine/threonine-protein kinase pim-3(Human)
Incyte

US Patent

LigandBDBM377188(US10265307, Example 37-2 | US10517858, Example 37 ...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.84 compound/DMSO in the assay buffer (...More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
10/19/2020
Entry Details
Copy Entry DOIGo to US Patent

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TargetSerine/threonine-protein kinase pim-1(Human)
Incyte

US Patent

LigandBDBM377188(US10265307, Example 37-2 | US10517858, Example 37 ...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
6/28/2021
Entry Details
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TargetSerine/threonine-protein kinase pim-2(Human)
Incyte

US Patent

LigandBDBM377188(US10265307, Example 37-2 | US10517858, Example 37 ...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
6/28/2021
Entry Details
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TargetSerine/threonine-protein kinase pim-3(Human)
Incyte

US Patent

LigandBDBM377188(US10265307, Example 37-2 | US10517858, Example 37 ...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
6/28/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetSerine/threonine-protein kinase pim-1(Human)
Incyte

US Patent

LigandBDBM377188(US10265307, Example 37-2 | US10517858, Example 37 ...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
5/29/2022
Entry Details
Copy Entry DOIGo to US Patent

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TargetSerine/threonine-protein kinase pim-2(Human)
Incyte

US Patent

LigandBDBM377188(US10265307, Example 37-2 | US10517858, Example 37 ...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
5/29/2022
Entry Details
Copy Entry DOIGo to US Patent

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TargetSerine/threonine-protein kinase pim-3(Human)
Incyte

US Patent

LigandBDBM377188(US10265307, Example 37-2 | US10517858, Example 37 ...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
5/29/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetSerine/threonine-protein kinase pim-1(Human)
Incyte

US Patent

LigandBDBM377188(US10265307, Example 37-2 | US10517858, Example 37 ...)Copy SMILESCopy InChI

Affinity DataIC50: 0.240nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2025
Entry Details
Copy Entry DOIPubMed
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TargetSerine/threonine-protein kinase pim-2(Human)
Incyte

US Patent

LigandBDBM377188(US10265307, Example 37-2 | US10517858, Example 37 ...)Copy SMILESCopy InChI

Affinity DataIC50: 30nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2025
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetSerine/threonine-protein kinase pim-3(Human)
Incyte

US Patent

LigandBDBM377188(US10265307, Example 37-2 | US10517858, Example 37 ...)Copy SMILESCopy InChI

Affinity DataIC50: 0.120nMMore data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2025
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL