BDBM376905 4-(3-fluorophenoxy)-2-{3H,4H,5H,6H,7H-imidazo[4,5-c]pyridin-5-yl}-6-(trifluoromethyl)pyrimidine (E36)::US9920053, Example 36

SMILES Fc1cccc(Oc2cc(nc(n2)N2CCc3nc[nH]c3C2)C(F)(F)F)c1

InChI Key InChIKey=YRSBMPKJFDYYFO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 376905   

TargetSodium-dependent dopamine transporter(Human)
Chronos Therapeutics

US Patent
LigandPNGBDBM376905(4-(3-fluorophenoxy)-2-{3H,4H,5H,6H,7H-imidazo[4,5-...)
Affinity DataIC50: 12.6nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetSodium-dependent noradrenaline transporter(Human)
Chronos Therapeutics

US Patent
LigandPNGBDBM376905(4-(3-fluorophenoxy)-2-{3H,4H,5H,6H,7H-imidazo[4,5-...)
Affinity DataIC50: 977nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Chronos Therapeutics

US Patent
LigandPNGBDBM376905(4-(3-fluorophenoxy)-2-{3H,4H,5H,6H,7H-imidazo[4,5-...)
Affinity DataIC50: 2.51E+3nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Human)
Chronos Therapeutics

US Patent
LigandPNGBDBM376905(4-(3-fluorophenoxy)-2-{3H,4H,5H,6H,7H-imidazo[4,5-...)
Affinity DataIC50: 1.00E+5nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent