BDBM376886 4-(aminomethyl)-1-(2-fluoro-3-phenoxyphenyl)piperidin-4-ol (E16)::US9920053, Example 16

SMILES NCC1(O)CCN(CC1)c1cccc(Oc2ccccc2)c1F

InChI Key InChIKey=VRCIMOVZBDBKFI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 376886   

TargetSodium-dependent dopamine transporter(Human)
Chronos Therapeutics

US Patent
LigandPNGBDBM376886(4-(aminomethyl)-1-(2-fluoro-3-phenoxyphenyl)piperi...)
Affinity DataIC50: 15.5nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetSodium-dependent noradrenaline transporter(Human)
Chronos Therapeutics

US Patent
LigandPNGBDBM376886(4-(aminomethyl)-1-(2-fluoro-3-phenoxyphenyl)piperi...)
Affinity DataIC50: 977nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Human)
Chronos Therapeutics

US Patent
LigandPNGBDBM376886(4-(aminomethyl)-1-(2-fluoro-3-phenoxyphenyl)piperi...)
Affinity DataIC50: 1.45E+3nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent