BDBM376849 (R)-(2-(1H-pyrazol-1- yl)phenyl)(2-((4-(2- hydroxypropan-2-yl)-5- methyloxazol-2- yl)methyl)piperidin-1- yl)methanone::US9920038, 10

SMILES Cc1oc(C[C@H]2CCCCN2C(=O)c2ccccc2-n2cccn2)nc1C(C)(C)O

InChI Key InChIKey=JFCNSYDHFOAHNY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 376849   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM376849(US9920038, 10 | (R)-(2-(1H-pyrazol-1- yl)phenyl)(2...)
Affinity DataIC50: 51nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM376849(US9920038, 10 | (R)-(2-(1H-pyrazol-1- yl)phenyl)(2...)
Affinity DataIC50: 129nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
Go to US Patent