BDBM376414 (R)-N-(1-(3- methoxyphenyl)ethyl)- 6H-isochromeno [4,3-d]pyrimidine- 8-carboxamide::US9914740, IX-3

SMILES COc1cccc(c1)[C@@H](C)NC(=O)c1ccc-2c(COc3cncnc-23)c1

InChI Key InChIKey=MEGGDKYEQSCVTG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 376414   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376414(US9914740, IX-3 | (R)-N-(1-(3- methoxyphenyl)ethyl...)
Affinity DataIC50: 2.39nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376414(US9914740, IX-3 | (R)-N-(1-(3- methoxyphenyl)ethyl...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of ROCK2 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM376414(US9914740, IX-3 | (R)-N-(1-(3- methoxyphenyl)ethyl...)
Affinity DataIC50: 38nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed