BDBM376373 (R)-N-(3- (pyrrolidin-2- ylmethyl- carbamoyl) benzyl)- 6H-isochromeno [3,4-c] pyridine-8- carboxamide::US9914740, VII-11

SMILES O=C(NC[C@H]1CCCN1)c1cccc(CNC(=O)c2ccc-3c(COc4cnccc-34)c2)c1

InChI Key InChIKey=NZRHMTUZAYUZTK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376373   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376373(US9914740, VII-11 | (R)-N-(3- (pyrrolidin-2- ylmet...)
Affinity DataIC50: 1.14nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
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