BDBM376111 (S or R)-2-fluoro-N-(1-(4- fluorophenyl)-3-(5-(1- hydroxyethyl)pyrimidin-2-yl)- 1H-pyrazol-5-yl)-5-(1-methyl- 1H-pyrazol-3-yl)-4- (trifluoromethyl)benzamide::US9914736, Compound 107

SMILES CC(O)c1cnc(nc1)-c1cc(NC(=O)c2cc(-c3ccn(C)n3)c(cc2F)C(F)(F)F)n(n1)-c1ccc(F)cc1

InChI Key InChIKey=JVZQBTVUGSSHTG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376111   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM376111(US9914736, Compound 107 | (S or R)-2-fluoro-N-(1-(...)
Affinity DataIC50: 1nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
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