BDBM376108 2-fluoro-N-(1-(4- fluorophenyl)-3-((1-methyl- 1H-tetrazol-5-yl)methyl)-1H- pyrazol-5-yl)-5-(pyrimidin-2- yl)-4- (trifluoromethyl)benzamide::US9914736, Compound 104

SMILES Cn1nnnc1Cc1cc(NC(=O)c2cc(-c3ncccn3)c(cc2F)C(F)(F)F)n(n1)-c1ccc(F)cc1

InChI Key InChIKey=UHUYZOHASDYVNA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376108   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM376108(US9914736, Compound 104 | 2-fluoro-N-(1-(4- fluoro...)
Affinity DataIC50: 1.60nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
Go to US Patent