BDBM376093 2-fluoro-N-(1-(4- fluorophenyl)-3-((5-oxo-4,5- dihydro-1,3,4-thiadiazol-2- yl)methyl)-1H-pyrazol-5-yl)- 5-(pyrimidin-2-yl)-4- (trifluoromethyl)benzamide::US9914736, Compound 89

SMILES Fc1ccc(cc1)-n1nc(Cc2n[nH]c(=O)s2)cc1NC(=O)c1cc(-c2ncccn2)c(cc1F)C(F)(F)F

InChI Key InChIKey=OYQDDQLMPSMRIV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376093   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM376093(US9914736, Compound 89 | 2-fluoro-N-(1-(4- fluorop...)
Affinity DataIC50: 4.80nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
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