BDBM376088 2-(5-(2-fluoro-5-(pyrimidin-2- yl)-4- (trifluoromethyl)benzamido)- 1-(4-fluorophenyl)-1H- pyrazol-3-yl)pyrimidine-4- carboxamide::US9914736, Compound 84

SMILES NC(=O)c1ccnc(n1)-c1cc(NC(=O)c2cc(-c3ncccn3)c(cc2F)C(F)(F)F)n(n1)-c1ccc(F)cc1

InChI Key InChIKey=NMFDNBSUQDCFIV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376088   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM376088(US9914736, Compound 84 | 2-(5-(2-fluoro-5-(pyrimid...)
Affinity DataIC50: 4.90nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
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