BDBM376029 N-(isothiazol-5-ylmethyl)-5'- methyl-5-({[3-(1-methyl-1H- pyrazol-3-yl)-4- (trifluoromethyl)phenyl] carbonyl}amino)-2'H-1,3'- bipyrazole-3-carboxamide::US9914736, Compound 25

SMILES Cc1cc([nH]n1)-n1nc(cc1NC(=O)c1ccc(c(c1)-c1ccn(C)n1)C(F)(F)F)C(=O)NCc1ccns1

InChI Key InChIKey=ARNYSLYJTDMKAX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376029   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM376029(US9914736, Compound 25 | N-(isothiazol-5-ylmethyl)...)
Affinity DataIC50: 1.70nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
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