BDBM376025 4-chloro-3-(4-methyl-1,3- thiazol-2-yl)-N-(1-phenyl-3- pyridin-4-yl-1H-pyrazol-5- yl)benzamide::US9914736, Compound 21

SMILES Cc1csc(n1)-c1cc(ccc1Cl)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccncc1

InChI Key InChIKey=NPFFCYOZKMNNKP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376025   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM376025(US9914736, Compound 21 | 4-chloro-3-(4-methyl-1,3-...)
Affinity DataIC50: 2.70nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
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